Wendy Macklin - Senior Editor

Dr Wendy Macklin is Professor and Chair of the Department of Cell and Developmental Biology at the University of Colorado Medical School in Denver. She is an internationally recognized authority on the molecular biology of myelin protein genes, particularly the myelin proteolipid protein gene, and she is studying animal models carrying mutations of this gene. She is investigating an alternative function for the myelin proteolipid protein in oligodendrocyte progenitor cell migration. She is interested in the molecular control of oligodendrocyte differentiation during brain development, and has generated transgenic mice to investigate the signalling pathways regulating myelination. She has developed rodent and zebrafish models to image oligodendrocyte differentiation in vivo, which provide real time information on the regulation of oligodendrocyte migration and differentiation.