Most read papers

Which papers are being downloaded the most?
The number of downloads in the 12 months to the end of April 2012 are shown below

1255	Review Molecules and mechanisms involved in the generation and migration of cortical interneurons Francesca Chiara, Luis Hernandez-Miranda and John Parnavelas (2010) 2, e0031 doi:10.1042/AN20090053 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1243	Review Mitochondria and Neuroplasticity Mark Mattson, Aiwu Cheng and Yan Hou (2010) 2, e0045 doi:10.1042/AN20100019 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1189	Prolonged exposure of cortical neurons to oligomeric amyloid-beta impairs NMDA receptor function via NADPH oxidase-mediated ROS production: protective effect of green tea (-)-epigallocatechin-3-gallate Yan He, Jiankun Cui, James Lee, Shinghua Ding, Malgorzata Chalimoniuk, Agnes Simonyi, Albert Sun, Zezong Gu, Gary Weisman, W. Wood and Grace Sun (2011) 3, e0050 doi:10.1042/AN20100025 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
1001	Dual vulnerability of Tau to Calpains and Caspase-3 proteolysis under neurotoxic and neurodegenerative conditions Ming Cheng Liu, Firas Kobeissy, Wenrong Zheng, Zhiqun Zhang, Ronald Hayes and Kevin Wang (2011) 3, e0051 doi:10.1042/AN20100012 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
980	Wnt5a controls neurite development in olfactory bulb interneurons Darya Pino, Youngshik Choe and Samuel Pleasure (2011) 3, e0059 doi:10.1042/AN20100038 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
957	The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and heme-oxygenase 1 Shao Lin, Lucia Lisi, Cinzia Dello Russo, Paul Polak, Anthony Sharp, Guy Weinberg, Sergey Kalinin and Douglas Feinstein (2011) 3, e0055 doi:10.1042/AN20100033 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
918	Review The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective V Hugh Perry and Vincent O'Connor (2010) 2, e0047 doi:10.1042/AN20100024 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
801	Review The curious case of NG2 cells: transient trend or game changer? Jean-Marie Mangin and Vittorio Gallo (2011) 3, e0052 doi:10.1042/AN20110001 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
733	T cell production of matrix metalloproteases and inhibition of parasite clearance by TIMP-1 during chronic Toxoplasma infection in the brain Robin Clark, J. Nance, Shahani Noor and Emma Wilson (2011) 3, e0049 doi:10.1042/AN20100027 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
690	Canonical Wnt signaling requires the BMP pathway to inhibit oligodendrocyte maturation Keith Feigenson, Mary Reid, Jill See, E. Crenshaw and Judith Grinspan (2011) 3, e0061 doi:10.1042/AN20110004 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
648	Review Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumor model Valerie Jacobs, Pablo Valdes, William Hickey and Joyce De Leo (2011) 3, e0063 doi:10.1042/AN20110014 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
644	Review Genetic mouse models of Huntington’s disease: focus on electrophysiological mechanisms Carlos Cepeda, Damian Cummings, Véronique André, Sandra Holley and Michael Levine (2010) 2, e0033 doi:10.1042/AN20090058 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
586	Apotransferrin-induced recovery after hypoxic-ischemic injury on myelination Mariano Guardia Clausi, Laura Pasquini, Eduardo Soto and Juana Pasquini (2010) 2, e0048 doi:10.1042/AN20100020 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
574	Inhibiting heat shock protein 90 reverses sensory hypoalgesia in diabetic mice Michael Urban, Chengyuan Li, Cuijuan Yu, Yuanming Lu, Joanna Krise, Michelle McIntosh, Roger Rajewski, Brian Blagg and Rick Dobrowsky (2010) 2, e0040 doi:10.1042/AN20100015 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
565	Review The multiple roles of myelin protein genes during the development of the oligodendrocyte Daniel Fulton, Pablo Paez and Anthony Campagnoni (2010) 2, e0027 doi:10.1042/AN20090051 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
556	*Increased Plp1* gene expression leads to massive microglial cell activation and inflammation throughout the brain** Carrie Tatar, Sunita Appikatla, Denise Bessert, Ajaib Paintlia, Inderjit Singh and Robert Skoff (2010) 2, e0043 doi:10.1042/AN20100016 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
549	Glial glucokinase expression in adult and post-natal development of the hypothalamic region Carola Millán, Fernando Martínez, Christian Cortés-Campos, Isabel Lizama, Maria Yañez, Paula Llanos, Karin Reinicke, Federico Rodríguez, Bruno Peruzzo, Francisco Nualart and Maria García (2010) 2, e0035 doi:10.1042/AN20090059 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
511	Review Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade Cristina Ghiani and Esteban Dell'Angelica (2011) 3, e0058 doi:10.1042/AN20110010 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
498	The neurogenic basic helix-loop-helix transcription factor NeuroD6 confers tolerance to oxidative stress by triggering an anti-oxidant response and sustaining the mitochondrial biomass Martine Uittenbogaard, Kristin Baxter and Anne Chiaramello (2010) 2, e0034 doi:10.1042/AN20100005 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
488	Review Hypothesis: are neoplastic macrophages/microglia present in glioblastoma multiforme? Leanne Huysentruyt, Zeynep Akgoc and Thomas Seyfried (2011) 3, e0064 doi:10.1042/AN20110011 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
477	Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus Neil Smalheiser, Giovanni Lugli, Angela Lenon, John Davis, Vetle Torvik and John Larson (2010) 2, e0028 doi:10.1042/AN20090055 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
477	Calorie restriction as an anti-invasive therapy for malignant brain cancer in the VM mouse Laura Shelton, Leanne Huysentruyt, Purna Mukherjee and Thomas Seyfried (2010) 2, e0038 doi:10.1042/AN20100002 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
476	Amyloid-β directly induces spontaneous calcium transients, delayed intercellular calcium waves, and gliosis in rat cortical astrocytes Siu-Kei Chow, Diana Yu, Christopher MacDonald, Marius Buibas and Gabriel Silva (2010) 2, e0026 doi:10.1042/AN20090035 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
461	Sex-specific activation of cell death signaling pathways in cerebellar granule neurons exposed to oxygen glucose deprivation followed by reoxygenation Jaswinder Sharma, Geetha Nelluru, Mary Ann Wilson, Michael Johnston and Mir Ahamed Hossain (2011) 3, e0056 doi:10.1042/AN20100032 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
461	Hyperglycemia and diabetes impair gap junctional communication among astrocytes Gautam Gandhi, Kelly Ball, Nancy Cruz and Gerald Dienel (2010) 2, e0030 doi:10.1042/AN20090048 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
459	Review Targeting VIP and PACAP receptor signaling: New therapeutic strategies in multiple sclerosis Yossan-Var Tan and James Waschek (2011) 3, e0065 doi:10.1042/AN20110024 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
453	Astrocytic gap junctional communication is reduced in amyloid-β-treated cultured astrocytes but not in Alzheimer’s disease transgenic mice Nancy Cruz, Kelly Ball and Gerald Dienel (2010) 2, e0041 doi:10.1042/AN20100017 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
442	Dual Induction of TREM2 and Tolerance related transcript, Tmem176b in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer’s disease Benoit Melchior, Angie Garcia, Bor-Kai Hsiung, Katherine Lo, Jonathan Doose, J. Thrash, Anna Stalder, Matthias Staufenbiel, Harald Neumann and Monica Carson (2010) 2, e0037 doi:10.1042/AN20100010 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
415	Glypican-1, phosphacan/receptor protein-tyrosine phosphatase-ζ/β and its ligand tenascin-C are expressed by neural stem cells and neural cells derived from embryonic stem cells Mary Abaskharoun, Marie Bellemare, Elizabeth Lau and Richard Margolis (2010) 2, e0039 doi:10.1042/AN20100001 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
390	Pre-Conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties Ellora Sen, Anirban Basu, Lisa Willing, Tracy Uliasz, Jaimie Myrkalo, Susan Vannucci, Sandra Hewett and Steven Levison (2011) 3, e0062 doi:10.1042/AN20100029 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
387	*Forebrain striatal-specific expression of mutant huntingtin protein in vivo* induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function** Soong Ho Kim, Carlos Thomas, Véronique André, Damian Cummings, Carlos Cepeda, Michael Levine and Michelle Ehrlich (2011) 3, e0060 doi:10.1042/AN20110009 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
376	A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death Sheila Semaan, Yan Li and Robert Nickells (2010) 2, e0032 doi:10.1042/AN20100003 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
371	Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells Makoto Yanagisawa, Saori Yoshimura and Robert Yu (2011) 3, e0054 doi:10.1042/AN20110006 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
355	Ganglioside metabolism in a transgenic mouse model of Alzheimer’s disease: Expression of Chol-1α antigens in the brain Robert Yu, Toshio Ariga, Makoto Yanagisawa, Chandramohan Wakade, Jerry Buccafusco, Michael MCDonald and Susumu Ando (2010) 2, e0044 doi:10.1042/AN20100021 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
354	Regulation of oligodendrocyte progenitor cell maturation by PPARdelta: effects on bone morphogenetic proteins Maria Simonini, Paul Polak, Anne Boullerne, Jeffery Peters, Jill Richardson and Douglas Feinstein (2010) 2, e0025 doi:10.1042/AN20090033 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
346	Oligodendrocyte Progenitor Cells Proliferate And Survive In An Immature State Following Treatment With An Axolemma-Enriched Fraction Sara Becker-Catania, Julie Nelson, Shantel Olivares, Shu-Jen Chen and George DeVries (2011) 3, e0053 doi:10.1042/AN20100035 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
344	Commentary Tolerating diabetes- an alternative therapeutic approach for diabetic neuropathy Nigel Calcutt (2010) 2, e0042 doi:10.1042/AN20100026 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
342	*Differential Levels of Glutamate Dehydrogenase 1 (GLUD1) in BALB/c and C57BL/6 Mice and the Effects of Over-Expression of Glud1* Gene on Glutamate Release in Striatum** Kevin Hascup, Xiaodong Bao, Erin Hascup, Dongwei Hui, Wenhao Xu, Francois Pomerleau, Peter Huettl, Mary Michaelis, Elias Michaelis and Greg Gerhardt (2011) 3, e0057 doi:10.1042/AN20110005 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
327	Cytotoxic effects of GM1 ganglioside and amyloid β-peptide on mouse embryonic neural stem cells Makoto Yanagisawa, Toshio Ariga and Robert Yu (2010) 2, e0029 doi:10.1042/AN20090063 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
307	Alterations in Striatal Synaptic Transmission are Consistent Across Genetic Mouse Models of Huntington’s Disease Damian Cummings, Carlos Cepeda and Michael Levine (2010) 2, e0036 doi:10.1042/AN20100007 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
300	Diverse inflammatory responses in transgenic mouse models of AD and the effect of immunotherapy on these responses Donna Wilcock, Qun Zhao, Dave Morgan, Marcia Gordon, Angela Everhart, Joan Wilson, Jennifer Lee and Carol Colton (2011) 3, e0069 doi:10.1042/AN20110018 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
266	Peripheral neuropathy in the Twitcher mouse involves the activation of axonal caspase 3 Benjamin Smith, Francesca Galbiati, Ludovico Cantuti-Castelvetri, Maria Givogri, Aurora Lopez-Rosas and Ernesto Bongarzone (2011) 3, e0066 doi:10.1042/AN20110019 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
238	Early Effects of Lipopolysaccharide-Induced Inflammation on Foetal Brain Development in Rat Cristina Ghiani, Natalia Mattan, Hiroko Nobuta, Jemily Malvar, Julie Boles, Michael Ross, James Waschek, Ellen Carpenter, Robin Fisher and Jean de Vellis (2011) 3, e0068 doi:10.1042/AN20110027 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
223	*YY1 Negatively Regulates Mouse Myelin Proteolipid Protein (Plp1) Gene Expression in Oligodendroglial Cells* Olga Zolova and Patricia Wight (2011) 3, e0067 doi:10.1042/AN20110021 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
212	Early Astrocytic Atrophy in the Entorhinal Cortex of a Triple Transgenic Animal Model of Alzheimer's Disease Chia-Yu Yeh, Bhamini Vadhwana, Alexej Verkhratsky and Jose Rodriguez Arellano (2011) 3, e0071 doi:10.1042/AN20110025 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
211	Increased Expression of Axogenesis-Related Genes and Mossy Fiber Length in Dentate Granule Cells from Adult HuD Overexpressor Mice Nora Perrone-Bizzozero, Daniel Tanner, Joanna Mounce and Federico Bolognani (2011) 3, e0070 doi:10.1042/AN20110015 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
205	Growth defects in the dorsal pallium after genetically targeted ablation of principal preplate neurons and neuroblasts: A morphometric analysis Robin Fisher and Yuan Xie (2010) 2, e0046 doi:10.1042/AN20100022 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
203	Sensory neurons derived from diabetic rats have diminished internal Ca²⁺ stores linked to impaired re-uptake by the endoplasmic reticulum Elena Zherebitskaya, Jason Schapansky, Eli Akude, Darrell Smith, Randy Van der Ploeg, Natasha Solovyova, Alexei Verkhratsky and Paul Fernyhough (2012) 4, e0072 doi:10.1042/AN20110038 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
151	Review Roles of white matter in CNS patho-physiologies Carlos Matute and Bruce Ransom (2012) 4, e0079 doi:10.1042/AN20110060 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF
141	Chronic excitotoxin-induced axon degeneration in a compartmented neuronal culture model Katherine Hosie, Anna King, Catherine Blizzard, James Vickers and Tracey Dickson (2012) 4, e0076 doi:10.1042/AN20110031 Abstract \| Enhanced Full Text \| Legacy HTML \| Full text PDF

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