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ASN NEURO (2009) 1(4):art:e00017.doi:10.1042/AN20090029

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Targeted overexpression of a golli–myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination

Erin C Jacobs*, Samuel D Reyes*, Celia W Campagnoni*, M Irene Givogri†, Kathy Kampf*, Vance Handley*, Vilma Spreuer*, Robin Fisher*, Wendy Macklin‡ and Anthony T Campagnoni*¹

*Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Neuroscience Research Building, 635 Charles Young Drive, Los Angeles, CA 90095, U.S.A.
†Department of Anatomy and Cell Biology, University of Illinois Chicago, 808 S. Wood Street #MC512, Chicago, IL 60612, U.S.A.
‡Department of Cell and Developmental Biology, University of Colorado Medical School, Aurora, CO 80045, U.S.A.

To whom correspondence should be addressed (email acampagnoni@mednet.ucla.edu).

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Figure S1 Severity and developmental timescale of the tremors in JOE mice

The hemizygous JOE mice exhibited a severe intention tremor that began at ˜P15 in the tail. With age, the tremor increased in intensity starting in the tail and involving more of the body as it moved progressively towards the head. By ˜P28, the tremor reached peak intensity, affecting the entire body. After P28, the tremor slowly began to abate progressively in the reverse direction, from head to tail. By P50–P60 the tremors are virtually unnoticeable. However, at ages beyond P50, the JOE mice still exhibited modest intention tremors when they had to locomote against resistance such as that experience when their tail is held in place as they attempt to move forward (i.e. supranormal proprioceptive load). A video of typical severity and body involvement in the tremor of a P28 JOE mouse can be viewed in Movie 1.

Received 14 July 2009/12 August 2009; accepted 14 August 2009

Published as ASN NEURO Immediate Publication 28 August 2009, doi:10.1042/AN20090029

©2009 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commerical use, distribution and reproduction in any medium, provided the original work is properly cited.