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Editorial Board
Editor-in-Chief
Anthony T. Campagnoni Los Angeles, U.S.A. Deputy Editor-in-Chief Reviews Editor Senior Editors  *Publication time subject to receipt of payment |
ASN NEURO (2009) 1(2):art:e00008.doi:10.1042/AN20090024
Commentary
When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation
Deirdre S Davis and Monica J Carson1
Division of Biomedical Sciences, Center for GlialNeuronal Interactions, University of California Riverside, 900 University Ave, Riverside, CA 92521, U.S.A.
Cite this article as: Deirdre S Davis and Monica J Carson (2009) When the tail can't wag the dog: the implications of CNS-intrinsic initiation of neuroinflammation. ASN NEURO 1(2):art:e00008.doi:10.1042/AN20090024
The CNS (central nervous system) is unquestionably the central organ that regulates directly or indirectly all physiological systems in the mammalian body. Yet, when considering the defence of the CNS from pathogens, the CNS has often been considered passive and subservient to the pro-inflammatory responses of the immune system. In this view, neuroinflammatory disorders are examples of when the tail (the immune system) wags the dog (the CNS) to the detriment of an individual's function and survival. Key words: autoimmunity, irradiation chimaeric mouse, MyD88, neurodegeneration, pathogen conserved molecular pattern (PAMP), Toll-like receptor Abbreviations: CNS, central nervous system, TLR, Toll-like receptor 1To whom correspondence should be addressed (email monica.carson@ucr.edu). Received 3 April 2009; accepted 22 April 2009 Published as ASN NEURO Immediate Publication 22 April 2009, doi:10.1042/AN20090024 ©2009 The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Licence ( |
ISSN: 1759-0914
Published by Portland Press Limited on behalf of the American Society for Neurochemistry |
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